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Symbol Name ID |
Ccr5
C-C motif chemokine receptor 5 MGI:107182 |
| Darker colors indicate more annotations |
| Human Phenotypes | Eosinophilia |
Increased T cell count |
Leukopenia |
Granulomatosis |
Sinusitis |
Conjunctivitis |
Keratoconjunctivitis sicca |
Abnormal lymph node morphology |
Lymphadenopathy |
Chronic otitis media |
Keratitis |
Episcleritis |
Uveitis |
Iridocyclitis |
Epididymitis |
Erythema nodosum |
Maculopapular exanthema |
Autoimmunity |
Anti-citrullinated protein antibody positivity |
Cytoplasmic antineutrophil antibody positivity |
Perinuclear antineutrophil antibody positivity |
Rheumatoid factor positive |
Asthma |
| Disease(s) Associated with CCR5 | |||||||||||||||||||||||
| asthma | |||||||||||||||||||||||
| Behcet's disease | |||||||||||||||||||||||
| granulomatosis with polyangiitis | |||||||||||||||||||||||
| rheumatoid arthritis | |||||||||||||||||||||||
| sarcoidosis | |||||||||||||||||||||||
| Sjogren's syndrome |
| Mouse Phenotypes | abnormal Kupffer cell morphology |
impaired macrophage chemotaxis |
abnormal cellular extravasation |
abnormal leukocyte adhesion |
decreased T cell proliferation |
decreased susceptibility to induced colitis |
decreased NK cell number |
increased NK T cell number |
abnormal CD4-positive, alpha beta T cell morphology |
abnormal CD8-positive, alpha beta T cell morphology |
abnormal leukocyte physiology |
increased IgG1 level |
abnormal NK T cell physiology |
decreased microglial cell activation |
abnormal cytokine level |
increased susceptibility to type IV hypersensitivity reaction |
abnormal cytokine secretion |
increased interferon-gamma secretion |
decreased interleukin-1 beta secretion |
increased interleukin-4 secretion |
decreased interleukin-6 secretion |
decreased susceptibility to endotoxin shock |
decreased inflammatory response |
bronchiolitis |
increased susceptibility to bacterial infection |
increased susceptibility to fungal infection |
decreased susceptibility to Retroviridae infection |
increased susceptibility to Coronaviridae infection |
increased length of allograft survival |
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| Availability | Mouse Genotype | |||||||||||||||||||||||||||||
| Ccr5tm1Blck/Ccr5tm1Blck | ||||||||||||||||||||||||||||||
| Ccr5tm1Brv/Ccr5tm1Brv | ||||||||||||||||||||||||||||||
| Ccr5tm1Kuz/Ccr5tm1Kuz | ||||||||||||||||||||||||||||||
| Ccr5tm1Sush/Ccr5tm1Sush | ||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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